In Vitro Evaluation of the Wound Healing Properties and Safety Assessment of Fucoidan Extracted from Sargassum angustifolium

Seaweeds are rich in fucoidan, which has various biologic effects. So far, a lot of research been conducted on the biological effects fucoidan extracted from species seaweed. However, partially purified extract Sargassum angustifolium (PPE-SA) wound healing (cell migration) adipose-derived mesenchymal stem cells (ADMSCs) have not yet studied. In this experimental study, crude was S. using an advanced method. After removing lipids, pigments and low molecular weight compounds with ethanol removal alginate CaCl2, polysaccharides remaining material were hot water (60ºC). The resulting precipitated ethanol. Then, safety PPE-SA ADMSCs investigated by MTT scratch assay, respectively. assay showed that did only negative effect growth but at some concentrations improved their up to 1.5 times. also increased migration 76% 142% after 48 h 72 incubation, superiority seaweeds over many other reported genera. results study seaweed obtained method potential promote may high for use tissue engineering applications.